P0607
Sigma
Anti-Presenilin-2, N-terminal antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
| Synonym: | Anti-AD3L, Anti-AD4, Anti-Presenilin 2 (Alzheimer 4), Anti-PS2, Anti-PSEN2, Anti-STM2 |
Description
| Immunogen | synthetic peptide corresponding to amino acids 7-24 of the N-terminal of human presenilin-2 (PS-2). The sequence is the same in mouse and rat. |
| Specificity | Detects an N-terminal proteolytic fragment. Additional bands are observed, probably corresponding to aggregated, modified, or intact PS-2. |
| Physical form | Solution in in 0.05 M sodium phosphate buffer, pH 7.5, containing 0.2% gelatin and 0.1% sodium azide. |
Properties
| antibody form | affinity isolated antibody |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| mol wt | antigen mol wt 28 kDa |
| species reactivity | mouse, rat, human |
| application(s) | immunoblotting: 1-2 μg/mL using mouse or rat brain extracts |
| immunohistochemistry (frozen sections): 2 μg/mL using 4% paraformaldehyde-fixed mouse brain tissue | |
| Gene Information | human ... PSEN2(5664) |
| rat ... Psen2(81751) | |
| mouse ... Psen2(19165) | |
| shipped in | wet ice |
| storage temp. | 2-8°C |
Safety
Related Products
| Comparable product | P0070, Anti-Presenilin-2, N-terminal antibody produced in rabbit |
References
| reference | Dewji, N.N., and Singer, S.J., Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc. Natl. Acad. Sci. U. S. A. 94, 9926-9931, (1997) Abstract |
